Empirical Antibiotic Treatment of Veterans with Chronic Osteomyelitis

Osteomyelitis is a bone infection that is caused by pyogenic bacteria، Mycobacterium tuberculosis، or fungus. This study has performed to determine the best experimental antibiotic treatment of chronic osteomyelitis due to Staphylococcus aureus infection. This cross-sectional study was conducted، on 145 war veterans with osteomyelitis from 2007 to 2011. T test method was used to find the sensitivity and antibiotic resistance in patients with Staphylococcus aureus. Our findings were classified to 3 categories: sensitive، resistant and moderately susceptible. The most effective antibiotic on S. aureus was Vancomycin that wasn’t resistance in none of the cultures، 36% of the cultures were sensitive to vancomycin. On the second category there was Ticoplanin with 5. 0% resistance. The most ineffective antibiotic was Cotrimoxazole that 73% of cultures were resistant to it. In 54. 8 percent of cultures staphylococcus were as reported resistance to Meticilin. In 107 % of Staphylococcus aureus resistant species were sensitive to cotrimoxazole. According to taking the culture is different at least from 24 hours to 15 days، prepared specimens in smear were observed from positive cocci. Vancomycin or Ticoplanin can be used to the time of preparation of culture results. To decide selecting each of these antibiotics many factors such as Cost، availability of medication، discharge، and drug side effects are important.