Effect of Anethum graveolens hydroalcoholic extract on pentylenetetrazole-induced paroxysm
AimsEpilepsy is one of the common neurological disorders. Today, there are many drugs for treatment of this disease, which most of these chemical drugs have harmful effects on patients’ health. The aim of the present study was to investigate the effect of hydroalcoholic extract of dill (Anethum graveolens) seeds on the pentylenetetrazole-induced chemical kindling.
MethodsThis experimental study was conducted on 50balb/c male mice weighting 25-35g. Mice were divided into five groups of 10. Three experimental groups received hydroalcoholic extract of dill seeds by three concentrations of 150, 300 and 600mg/kg of the animals’ body weight. Positive control group received diazepam (3mg/kg) instead of the extract. Likewise, negative control groups received sterile normal saline (6mg/kg) instead of the extract. In order to exactly compare the different concentrations of the drug and extract on the times after injection on the paroxysm values, ANOVA and supplementary Tukey test as well as SPSS 18 software were used.
ResultsAt doses of 150 and 300mg/kg, dill had desirable inhibitory effect on the epileptic behavior of animals at different days (p<0.01). Moreover, at dose of 600mg/kg, it favorably inhibited the mice’ epileptic movements (p<0.01).
ConclusionThe hydroalcoholic extract of dill seeds has antiepileptic (anti-seizure) effect at dose of 600mg/kg on mice.
Quarterly of Horizon of Medical Sciences, Volume:19 Issue:1, 2013
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