Polymorphism in CCR4 Gene (1014 C/T) in Patients with Breast Carcinoma from the South of Iran

CCR4 gene polymorphism at position C/T1014 has been associated with changes in mRNA stability and is involved expression of this molecule. The aim of this study was to investigate CCR4 gene polymorphism at position 1014 C/T in breast carcinoma patients in southern Iran. Material & Methods In this case-control study, 150 women with breast carcinoma and 160 healthy women as controls were included. PCR-RFLP method was used to genotyping of CCR4, receptor gene. The data were analyzed using chi-square and Fisher. Genotype frequencies of CC, CT and TT, in case group were 57.8, 35.1 & 7.1%, where as in control group showed 54.4, 39.4 & 6.2% respectively. In addition, C and T allele of the cases were, 75.3 & 24.7% and in control group 74.1 & 25.9% respectively (p>0.05). CCR4 gene polymorphism has no role in increasing of susceptibility to breast cancer in the south of Iran population.