Extract on Exprimental Diabetes in Rats Evaluation Effect of Shrimp(Fenneropenaeus Indicus)

The present study was conducted to compare the effects of shrimp extract، glibenclamide and vanadium on blood glucose fluctuations in diabetic rats. Diabetes was induced by streptozotocin in six groups of male rats (each group contain 7 rats). The group 1 was kept as control group at similar conditions to other groups. Glibenclamide (10mg/kg)، vanadium (10mg/kg)، shrimp extract (orally -500mg/kg) and shrimp extract (intraperitoneally-200mg/kg) was administrated in group 2 to 5 respectively on 8th day after streptozotocin injection. The drugs were administrated every 2 days from day 8 to 18 after streptozotocin injection. The group 6 received extract (intraperitoneally-200mg/kg) from day 1 to 18 daily. The blood glucose was measured before drugs administration and 1، 3 and 24 hours after that and at 15th day of study. Serum glycosilated hemoglobin was measured at 18th day. The results shown that the shrimp extract had significantly prophylactic effect on severity of diabetes and prevented blood glucose elevation in comparison to other groups. However، prophylactically admin-istration of extract increased serum glyc-osilated hemoglobin level. The orally adm-inistration extract decreased blood glucose 1 and 24 hours later. However، glibencla-mide and vanadium did not affect the blood glucose level significantly. Discussion & The present study showed the shrimp extract may have protective effect on severity of diabetes; but it is needed more detailed researches