Study of Antibiotical Effects of Scrophularia Striata With Tetracyclin Aqueous Extract on E. Coli in Comparison With Tetracyclin
Message:
Abstract:
Introduction
Since bacteria became resistant to some types of antibiotics، it is prominent to find more reliable sources against them. In view of the fact that plants have been shown verity of biological eff-ects، they could be promising substitutions. Inasmuch as Scrophularia has shown differ-rent biological properties such as antimic-robial، antitumor and anti-inflammatory activities، its effect on Escherichia coli has been evaluated.
Material and Methods
Antibiotic effects of both filtered and nonfiltered extract of Scro-phularia striata on Escherichia coli as gram-negative bacterium were evaluated by spectrophotometery method. Simultaneou-sly tetracycline was used as a positive control at different concentrations. In addi-tion، MTT assay was applied for cell surv-ival determination.
Findings
Our findings indicate that conc-entrations between 1 to 20 µg/ml of the extract have significant antibiotic activities; there is no noticeable difference between filtered and nonfiltered antibiotic activities of this extract. Moreover، this effect is totally different from inducing properties of the extract. Discussion &
Conclusion
In conclusion، 5 µg/ml of the extract has a significant antibiotic activity whereas there is not such an effect on fibroblast cells. In view of the fact that this concentration of the extract has a potential antibiotic activity accomp-anied with considerable low side effects on human cells، Scrophularia striata extract can be regard as a potential antibiotic agent in the future.
Language:
Persian
Published:
Ilam University of Medical Science, Volume:20 Issue: 4, 2013
Pages:
127 to 133
magiran.com/p1116919  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!