Review of Enterotoxigenic Escherichia coli bacteria vaccines

Enterotoxigenic Escherichia coli is the most common bacterial agent producing diarrhea in the world wide. This bacterium includes some virulence factors such as; colonization factors and heat-labile toxin and/ or heat-stable toxin. Enterotoxigenic Escherichia coli attached to the intestinal epithelial cell surface through CFs and causes diarrhea by toxin secretion. Molecular pathogenesis stu-dies demonstrate that there are many pro-phylactic approaches for this infection. The best possible way is designing and prod-ucing efficient vaccine that enabeling to induc protective immunity against the most of bacterial strains. Vaccine candidate molecule (s) that are used to design a vaccine، in addition to possess immuno-genicity and safety; they should be wid-espread among variety of strains and co-ntain conserved and common epitops. This article pays attention to review some infor-mation and results of conducted researches on enterotoxigenic Escherichia coli vaccine and importance of the bacteria and its pathogenesis.