Effect of regular resistance exercise on C-peptide vascular function in diabetic rats

Many evidence showed that exercise training has beneficial effects on skin blood flow in the health and diabetic condition. On the other hand some finding showed that C-peptide has protective and therapeutic effect on vascular dysfunction-induced by diabetes. Therefore the purpose of this study is effects of resistance exercise on vascular function of C-peptide. In this experimental study، Male wistar rats (220±10g، N=30) were used in two diabetic (control and trained) and one age-matched healthy control groups. After 1 week of diabetes induction، animals were submitted to resistance exercise training for 9 Weeks on ladder. To characterize cutaneous micro vascular responses by Laser Doppler flowmetery، animals were deeply anesthetized by intraperitoneal injection of pentobarbital sodium (50 mg/kg). For data analysis، one-way ANOVA test was used to compare the groups. Statistically significant difference between the minimum acceptable levels is p<0. 05 Local microinjection of c-peptide increased coetaneous blood flow in trained and control diabetic rats، however this effect in trained group is higher than control diabetic group rats. Administration of Nw-nitro-L-arginine (nitric oxide synthase inhibitor) before C-peptide reduced significantly C-peptide vascular effects in trained and control diabetic rats. Chronic resistance exercise potentiate C-peptide vascular function، possibly by nitric oxide pathway