Interactive Effects of Regular Endurance exercise and Plant Antioxidant Supplementation on Chronic Inflammation Caused by Induction of Nitric Oxide Synthase Inhibitors

For the study of interactive effects of endurance exercise and plant anti oxidant supplement on inflammatory markers, including vascular adhesive molecules (VCAM-1) and reactive protein with high sensitivity (HS-CRP) and antiinflammatory such as angiotensin converting enzyme inhibitors (ACE-I) in the hypertensive caused by induction of nitric oxide synthase inhibitors (iNOS), 48 mice randomly dividede into six groups: 1) basic, 2) sham, 3) iNOS 4) Ferula gummosa boiss 5) endurance 6) Ferula gummosa boiss+exercise. Groups 3 to 6, five sessions per week for eight weeks, 10 mg / kg dissolved iNOS were as the peritoneal. Group 5 and 6 endurance running exercise protocol on a treadmill with a speed of 15 to 20 meters per minutes 5 times a week for 8 weeks were performed.Group 4 and 6, 90 mg / kg 5 times a week using a solution of Ferula gummosa boiss gavage for 8 weeks and group 2 received saline with same conditions. The laboratory and statistical analysis revealed that induction of iNOS leads to hypertensive and reduced the angiotensin converting enzyme inhibitors ACE-I. Furthermore, hypertensive was associated with increase at vascular adhesive molecules (VCAM-1) and HS-CRP. The exercise protocols and Ferula gummosa boiss was only inhibit the harmful effects of hypertensive associated with induction of iNOS. However, using the combined method (endurance training+ Ferula gummosa boiss) can reverse the effects of basic and sham groups were compared. Based on these results, hypertensive is associated with vascular damage, and a combination of regular activity and ani-oxidative supplements can be used as a non-medical strategies to control and combat the effects of chronic hypertensive.