Effect of Combined Regular Running Exercise and Plant Extracts on Functional and Glomerular Sclerosis Indicators of Kidney in Chronic Hypertension

The aim of this study was to determine the effect of combined Regular exercise treadmill running and plant extracts on functional consist to creatinine and Blood urea nitrogen(BUN) and structural (glomerular sclerosis) indicators of kidney in chronic hypertension. For this purpose, thirty male Wistar rats were randomly divided into 4 groups (Basline, Sham-operate, L-NAME and combination of exercise and supplement groups. For the hypertension, L-NAME is administrated with 10 mg/kg dosage, intraperitoneally (i.p), for 8 weeks and 6 sessions a week in L-NAME and exercise and supplement groups. Training protocol was performed 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks on treadmill. Ferula gummosa was administered with 90 mg/kg per day dosage for 8 weeks using gavage. The sham group received saline solution with the same conditions. Baseline group also did not participate in any intervention. ANOVA showed, administration of L-NAME led to hypertension (It was found that increased activity of angiotensin-converting enzyme or ACE) As well as significant increases in blood urea nitrogen (BUN) and creatinine compared with baseline and sham groups. Results showed that combined aerobic exercise and plant Ferula gummosa extracts reduced the ACE and reduced levels of function indicators of kidney compared with L-NAME groups. The glomerular sclerosis was observed in L-NAME group but was not observed Ferula gummosa + exercise group. The findings of this study can be using approaches such as regular running exercise along with Ferula gummosa plant as a plant antioxidant with inhibiting hypertension can have positive effects on function and structural of kidney in hypertensive patients.