The Effect of adipokines secreted from adipose tissue on immune function in obese subjects
Message:
Abstract:
Obesity is characterized as a state of systemic low-grade inflammation suggesting a link between metabolism and immune function. obesity has been shown to predispose individuals to an increased risk of many diseases.Since 1980s, a threefold increase in obesity has been reported in much of the world.obesity is a result of energy imbalance. one of the components that control energy balance is adipocyts metabolism that secrets adipokines. Many of the receptors for these adipokines are expressed on immune cells, providing a route of direct impact on immune cell function. Also the role of adipose tissue on immune system was determined by some cytokines that were secreted by adipocytes and called adipokines this means that adipose tissue is not only use for energy store but also is a endocrine organ in body. these adipokines are Leptin,Adiponectin, Resistin and Visfatin. leptin reduces food intake. adiponectin increases fatty acid oxidation and reduces glucose synthesis in liver. also has a function on inflammation and immune components. resistin has an anti insulin function, also resistin is in adipocytes, macrophages and other cells and has a role in inflammation condition in body. Visfatin mimics insulin behavior. It appears that effect of obesity on immunity has two edeges role because leptin attenuates immune system and also increases inflammation and adiponectin reinforces immunity.
Language:
Persian
Published:
Iranian Journal of Nutrition Sciences & Food Technology, Volume:7 Issue: 5, 2013
Page:
887
magiran.com/p1125596  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!