Effect of Supplementation with Grape Seed Extract (Vitis vinifera) on Serum Lipid Profiles in Patient with Type 2 Diabetes Print

Lipid abnormalities are a major cause of cardiovascular diseases in patients with type 2 diabetes. The present study was therefore designed to investigate the supplemental effects of grape seed extract on serum lipid profiles of patients with type 2 diabetes.

The study was a randomized، triple-blind، clinical trial in which 48 patients with type 2 diabetes were randomly assigned to 2 groups، the grape seed extract supplement and the placebo group. The patients in the grape seed extract group received 200 mg/d grape seed extract for 8 weeks while the placebo group received a corresponding placebo. At baseline and or the end of the 8th week of the study، 5 ml blood was collected after a 12 to 14-hour fast from each patient and serum triglycerides، total cholesterol، HDL-C، and LDL-C were measured.

There were no significant differences between the two groups with regard to mean changes of serum trigl ycerides، total cholesterol، HDL-C، and LDL-C.

The results of the present study indicate that grape seed extract supplement has no effect on serum lipid profiles in patients with type 2 diabetes.