Antimicrobial and Antifungal Effects of Acid and Water-Soluble Chitosan Extracted from Indian Shrimp (Fenneropenaeus indicus) Shell

Currently، efforts are underway to seek new and effective antimicrobial agents، and marine resources are potent candidates for this aim. The following study was conducted to investigate the efficacy of water-soluble and acid-soluble chitosan against some pathogenic organisms. Materials & Method s: Inhibition zone of different concentrations (5، 7. 5، and 10 mg/ml) of acid- soluble and water-soluble chitosan were examined for in vitro antibacterial activity against 4 kinds of hospital bacteria and penicillium sp. Results were compared with 4 standard antibiotics: streptomycin، gentamicin، tetracycline، and erythromycin. Furthermore، minimum inhibitory concentration and minimum lethal concentration were determined. Inhibition activity of acid-soluble chitosan (10%) showed the best result (p value < 0. 05)، whereas water-soluble chitosan exhibited the least antibacterial effects (p value < 0. 05). Chitosan demonstrated maximum effect on V. cholera cerotype ogava، and the least effect was seen on E. coli (p value < 0. 05). Acid-soluble chitosan had a more potent effect than the standard antibiotics. Also، acid-soluble chitosan (10%) and water-soluble chitosan showed maximum inhibitory effects on penicillium sp. Chitosan showed maximum antibacterial effect against S. aureus، V. cholerae cerotype ogava، and water-soluble chitosan demonstrated good antifungal effects، revealing a statistically significant difference with common antibacterial and antifungal medicines.