The effect of continuous treadmill exercise on heat shock protein 72 and total antioxidant capacity level in the plasma of streptozotocin_induced diabetic rats
Message:
Abstract:
Background And Aim
HSP72 and TAC are two factors from internal defense of body. The purposeof this study was to investigate the effects of acute treadmill exercise on HSP72 in the plasmaof diabetic rats.
Materials And Methods
Forty male rats weight 165±1 were assigned randomlyinto 4 groups: diabetic control group, and 3 diabetic+acute training groups, (included groups 1and2, and 3 that were killed 30 minute, 4 hours and 24 hours postexercise respectively). Diabetes wasinduced with injecting streptozotocin (dissolved in 0.1 M citrate buffer, pH 4.5) into the abdominalcavity. Rats were subjected to treadmill exercise, and the speed of the treadmill was 10 m/min,and then gradually increased until 18 m/min (grade 0%). The duration of the treadmill exercise was60 minutes. For determination of HSP72 and TAC values, respectively sandwich Elisa and decolorizationwere used.
Results
Acute exercise training increased the plasma HSP72 in the groups2 and 3, but in group 1 no significant changes took place. HSP72 levels significantly increasedin the group 2 (P=0.03) and 3 in compared with groups 1 and 2 (P=0.001 and P=0.005 respectively).Increase in TAC levels only in group 3 compared to control group was significant (P=0.03).
Conclusion
These results show that acute treadmill exercise improved HSP72 levels and TACin diabetic’s subjects and have benefit effects. Therefore probably acute exercise treadmill couldrecommend as a therapeutic strategy for diabetes.
Language:
Persian
Published:
Journal of practical studies of Biosciences in Sport, Volume:1 Issue: 1, 2013
Page:
34
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