Comparison of Ondansetron and Meperidine in treatment of post anesthesia shivering- A randomized placebo controlled triple blind clinical trial

Backgrounds and post anesthesia shivering increases the oxygen requirement up to 500%، post operative pain، post operative nausea and vomiting، blood pressure، intra –ocular pressure، intracranial pressure، and prolongs recovery stay. Meperidine is one of the most useful drugs for treatment and prevention of this condition but would lead to common side effects of opioids. Addressing an effective drug with less adverse reactions، we compared the therapeutic effects of Ondansetron and Meperidine. Methods and Materials: This randomized triple blind placebo controlled clinical trial examined 206 patients were divided into three groups. Statistical analysis was done using paired T-test. All patients were analyzed in the group as they were randomized (Intension to treat). All statistical analysis performed in SPSS-18 software. The difference between three groups was significant in particular treated patients with meperidine group (P<0. 001). The number mepredine group was significantly more than 50%while the number of patients treated with Ondansetron was 50% and showed no significant difference. The number of patients treated with placebo was significantly lesser than 50%. Meperidine is more effective than Ondansetron in treatment of post anesthesia shivering notwithstanding، ondansetron is an appropriate therapy in some conditions.