Nicolau Syndrome Following Intramuscular Penicillin Injection

Nicolau Syndrome (NS) is a rare but severe localized adverse reaction at the site of intramuscular drug injection. The typical presentation is intense pain around the injection site soon after injection، followed by erythema، purplish network discolouration of the skin (livido reticularis)، haemorrhagic patch، and finally tissue necrosis. Here in، we report a 7years old boy، the forth Nicolau Syndrome (NS) reported from Iran after a single intramuscular injection of penicillin.