Evaluation of lipid profile and oxidative stress indices in serum and liver of rat after iron-oxide nanoparticle administration

Considering the importance of iron and the role of oxidative stress in its toxicity, the purpose of this study was to compare the effect of nano iron-oxide on oxidative stress indices and lipid profile in serum and liver of rats.

In this experimental study, 15 rats were allocated into 3 groups; the control and the other two groups were interaperitoneally received either nano or conventional iron-oxide (8mg/kg) daily for 15 days. The amount of malondialdehyde (MDA), antioxidant activity (AOA), triglyceride (TG) and cholesterol in serum and liver; carbonyl protein and total lipid in liver and LDL, VLDL and HDL in serum of rats were determined.

Liver AOA was significantly increased by nano and conventional iron-oxide (P=0.02). MDA in serum was significantly decreased (P=0.001), but in liver increased (P=0.04) in the group received nano iron-oxide compared with the other two groups. Moreover, carbonyl protein was significantly increased by nano and conventional iron-oxide (P=0.05). TG and VLDL levels were decreased but LDL was increased by nano and conventional iron-oxide (P=0.02).

According to the results of the study, nano iron-oxide can increase oxidative stress in liver and induce arthrosclerosis.