The Effect of Resistance Training Intensity on Serum ApoA-I Concentration in Streptozotocin-Induced Diabetic Rats

Cardiovascular disease is the major cause of death in persons with type 1 diabetes. Although physical activity has been associated with a reduction in cardiovascular mortality in type 1 diabetes patients، there is limited information available regarding physical activity، resistance in particular، resistance training on the lipid profiles and apolipoprotein A-I (apoA-I) in these patients. The aim of this study was to investigate the effects of 4 weeks resistance training on serum lipid profiles and apoA-I levels in type 1 diabetic rats. Thirty-two male Wister rats (290 ± 20 g) were randomly divided into four groups: Healthy control (C)، diabetic controls (DC)، diabetic، trained with 50% body mass (DT1)، and diabetic، trained with 100% body mass (DT2). Resistance training consisted of climbing a ladder carrying a load suspended from the tail. After 4 weeks of resistance training، serum lipid profiles، glucose and apoA-I concentr­ations were measured. At the end of study، we found no significant differences in serum lipid profiles and glucose concentrations between the diabetic groups. In the DT2 group، serum apoA-I levels significantly increased، compared with the C and DC groups (P<0. 001 and P= 0. 023، respectively). Serum apoA-I concentrations، in streptozotocin induced diabetic rats، are increased by resistance training، the alterations being affected by its intensity، without any significant changes in their lipid profiles.