Assessing the effects of silver nanoparticles on some hematological parameters during the wound healing in mice

Although nanosilver (Ag-NPs) has long been used to treat wounds، little attention has been paid to the toxicity of nanosilver wound dressing. This study aimed to examine the effect of nanosilver used for wound healing on some hematological parameters. In this experimental study، 50 BALB/c mice were randomly allocated into the treatment and control groups (n=25). After creating similar wound on the back of all animals، the wound bed in the treatment and control groups was treated with a volume of 50 microliters nanosilver solution (10ppm)، and distilled water. Afterwards، the mean percentage reduction in wound area was determined at the end of each week by measuring the wound area at 0، 7 and 14 days post-wounding. MCV، distribution range of RBC، hematocrit and the number of blood cells were measured for both groups. By the end of the second week، a significant reduction was observed in the mean wound area in the treatment group. In treatment group، the number of white blood cells was increased; however، no significant changes in the number of RBCs and other blood parameters were observed. Application of nanosilver wound dressing not only can accelerate healing process، but also can stimulate the immune system with no adverse effect on some hematological parameters.