Antinociceptive and Anti-Inflammatory Effects of Matricaria Chamomilla L. in Male Mice

Due to the negative role of inflammation and pain in the treatment of the diseaes, and in the absence of proper medical treatment because of the side effects of chemical drugs, this study was done to evaluate the function of chamomile herb to fix swelling and to relieve pain. In other words, anti-inflammartory and anti-nociceptive effects of hidro-alcholic extract of matricaria chamomilla L. was evaluated. In this study, 144 male NMRI mice weighting 20-25 g were divided in 6 groups: control (receiving saline), positive control (receiving dexamethasone at dose of 15 mg/kg or morphine at dose of 10 mg/kg) and four groups receiving doses (500, 600, 800, 1000 mg/kg) of hydro-alcoholic extract of chamomile. Inflammation was induced by subcutaneous injection of formalin into the plantar and xylene to hear. Nociception was also caused by intraperitoneal injection of acetic acid. The amount of inflammation was measured by the diameter of the bottom feet by caliper and weight of the 7 mm of ear cut and comparing them with the control group. As well as the amount of antinociception was also measured by the number of abdominal stretch and compared with the control group. Hydro-alcoholic extract of chamomile reduces swelling of feet and ears and abdominal pain. These reductions are evident, especially in high doses 800 and 1000 mg/kg (p <0.001 & P <0.05). Considering the findings, extract of chamomile is effective in reducing of inflammation and pain.