Frequency of HER-2 over Expression in the Patients with Breast Cancer after Mastectomy

HER-2 is a protein receptor of growth. Approximately 25% of breast cancers have overexpress HER-2. This study was designed to determine frequency of HER-2 overexpression in patients with breast cancer. Additionally، it intended to explore its relationship with some variables such as age، histopathologic diagnosis،tumor size، axillary lymph node involvement. This analytic cross-sectional study was conducted on patients with breast cancer whose breast tissue specimen was referred to pathology laboratory of Shahid Sadooghi hospital of Yazd during 1389 and 1390. In our study، 147 patients were investigated who were all females with average age of 50. 34 years with 13. 3 years standard deviation. 54. 5% of them were HER-2/neu positive and frequency of HER-2 was higher in patients with older age، larger size tumor، ductal carcinoma diagnosis and axillary lymph node involvement، though there wasn''t any statistically significant difference between these variables and HER-2 overexpression. In our study، frequency of Her-2 overexpression was more than other studies and frequency of HER-2 was higher in patients with older age، larger size tumor، ductal carcinoma diagnosis and axillary lymph node involvement but there wasn''t any statistically significant difference between these variables and HER-2 overexpression. Regarding high frequency of HER-2 overexpression in this study that can be duo to genetic and ethnic variations، we recommend that HER-2/neu screening test should be done in all patients with breast cancers specially those with ductal carcinoma diagnosis، larger size tumor and axillary lymph node involvement.