Identification of Xq22.1-23 as a region linked with hereditary recurrent spontaneous abortion in a family
Author(s):
Abstract:
Objective
In this study we performed linkage analysis on a large X linked RSA pedigree to find a novel susceptibility locus for RSA. Materials And Methods
A linkage scan using 11 microsatellites was performed in 27 members of a large pedigree of hereditary X-linked RSA. Two point parametric Linkage was performed using Superlink v 1.6 program. Results
Evidence of linkage was observed to markers at Xq23, DXS7133 and at Xq22.1 DXS101, with LOD score of 3.12 and 1.60, respectively. Conclusion
Identified locus in this study may carry a responsible gene in RSA. Narrowing down of this region may leads to identification of this gene Recurrent spontaneous abortion (RSA) is one of the most common health complications with a strong genetic component. Several genetic disorders were identified as etiological factors of hereditary X linked RSA. However, more genetic factors remain to be identified.Keywords:
Language:
English
Published:
International Journal of Reproductive BioMedicine, Volume:11 Issue: 8, Aug 2013
Pages:
659 to 664
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