Alpha-1 Antitrypsin Deficiency in Iranian Patients with Chronic Obstructive Pulmonary Disease
Message:
Abstract:
Background
Alpha-1 antitrypsin deficiency is a genetic disease which affects both lung and liver. This disease is a recognized factor for chronic obstructive pulmonary disease (COPD). However its importance as the cause of COPD in a country such as Iran is unclear..
Objectives
This study was conducted to find out the role of α-1 antitrypsin deficiency as a cause of COPD in Iranian patients..
Materials And Methods
The serum concentration of α-1 antitrypsin was determined and the genotype of α-1 antitrypsin was also evaluated by PCR-RFLP in 130 patients with COPD and 50 normal healthy blood donors..
Results
No α-1 antitrypsin deficient case was found in normal healthy people and COPD patients..
Conclusions
Our results clarify that deficiency of α-antitrypsin is not a major cause of COPD in Iranian patients..
Language:
English
Published:
Iranian Red Crescent Medical Journal, Volume:15 Issue:11, 2013
Page:
7508
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