Myocardial Dysfunction: A Primary Cause of Death Due To Severe Malaria in A Plasmodium falciparum-Infected Humanized Mouse Model
Message:
Abstract:
Background
Our study aimed at substantiating the recent claim of myocar­dial complications in severe malaria by experimentally inducing severe Plasmodium falciparum infection in a humanized mouse model employed as human surrogate.
Methods
Twenty five humanized mice were inoculated with standard in vitro cultured P. falciparum and blood extracts collected from the inner cardiac mus­cles of infected mice that died were examined for the presence of the infectious cause of death. The therapeutic effect of quinine on 7 mice se­verely infected with P. falciparum was also evaluated.
Results
All the 25 humanized mice inoculated with the in vitro cultured P. falciparum revealed peripheral parasitemia with a total of 10 deaths recorded. Postmortem examination of the inner cardiac muscles of the dead mice also revealed massive sequestration of mature P. falciparum as well as significant infiltration of inflammatory cells such as lymphocytes and monocytes. Postmor­tem evaluation of the inner cardiac muscles of the P. falciparum-in­fected mice after quinine therapy showed significant decline in parasite den­sity with no death of mice recorded.
Conclusions
Data obtained from our study significantly corroborated the findings of myocardial dysfunction as the primary cause of death in recent case reports of humans infected with P. falciparum.
Language:
English
Published:
Iranian Journal of Parasitology, Volume:8 Issue: 4, Oct-Dec 2013
Pages:
499 to 509
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