The effect of 8 weeks moderate intensity aerobic exercise on plasma Apelin level and insulin resistance in women with type 2 diabetes

there are many different mediators such as Apelin that have effective role of regular aerobic exercise، on metabolic disorders and type 2 diabetes mellitus. The aim of present study was to investigate the effect of 8 weeks aerobic exercise on plasma apelin level and insulin resistance index in women with type 2 diabetes mellitus.

Eighteen diabetic women (aged 53/61± 6/90 yrs) selected as subjects and were randomly assigned into two exercise (n=9) and control (n=9) groups. Exercise training was performed 3 days a week with intensity corresponding to 60-70% HRmax for 8 weeks.

The body weight was decreased in exercise group after 8 weeks exercise training (p<0. 01). VO2max was increased and plasma Apelin، insulin levels and HOMA-IR index was decreased in the exercise group compare to pre-exercise and control groups (p<0. 01).

It was concluded that the changes in Apelin level and HOMA-IR are involved in the decrease of the body weight and anti-inflammatory nature of exercise.