Effect of CoQ10 supplementation on blood pressure, inflammation, and lipid profile in type 2 diabetics

Diabetes is a metabolic disorder associated with inflammation. Coenzyme Q10 (CoQ10) is a natural compound that has recently been regarded as an anti-inflammatory substance. The present study assessed the effect of CoQ10 supplementation on blood pressure، inflammation، and lipid profile in type 2 diabetic patients. Fifty-two subjects diagnosed with type 2 diabetes participated in a randomized، single-blind، placebo-controlled clinical trial. The subjects were randomly divided into two groups: one received CoQ10 supplements)100 mg twice a day (and the other received two placebos for 8 wks. Systolic and diastolic blood pressure was recorded for each participant before and at the end of week 8. Blood samples were obtained at baseline and at the end of the intervention after an overnight fast. These were analyzed for the inflammatory marker (hs-CRP) and lipid profile (triglyceride، total cholesterol، LDL-C and HDL-C). CoQ10 supplementation resulted in a significant decrease in systolic blood pressure over the control group (p = 0. 001). A comparison of the parameters within groups demonstrated that systolic blood pressure decreased in the CoQ10 group (p < 0. 001) and hs-CRP increased in the placebo group (p = 0. 03). No changes were observed for lipid profile. CoQ10 supplementation may decrease systolic blood pressure in type 2 diabetic patients and may help prevent the elevation of inflammation in this group of patients.