The comparison of two methods of oral misoprostol and intravenous oxytocin for success of labor induction in premature rupture of membrane

Premature rupture of membranes (PROM) occurs in 8-10% of pregnancies at term and the long interval between premature rupture of membranes (PROM) and labor increase significant maternal and neonatal infections. The aim of this study is to compare two methods of oral misoprostol and intravenous oxytocin for labor induction in the women with PROM and unfavorable Bishop scores. 240 women with PROM, the gestational age higher than 36 weeks and unfavorable Bishop scores were randomly divided two groups: (group 1: 75µg of misoprostol every 4 hours with maximum of two doses plus ringer serum and group 2: 2 mIU/min of intravenous oxytocin and increased 2 mIU/min every 10 minutes plus placebo tablet). Misoprostol group was shorter in the time interval between vaginal deliveries compared with oxytocin group. The average of this interval for the misoprostol group was 11.02 hours comparing with 12.25 hours (P = 0.003) for the intravenous oxytocin group. In addition, the percentage of women with underwent cesarean delivery was also lower in the misoprostol group, having similar tachysystole and hyperstimulation side effects for both groups. Discussion & Inclusion: In women at term with PROM, oral misoprostol, comparing oxytocin, is a safe, economic and suitable alternative for inducing delivery.