Effects of jujube fruit powder to prevent increases in glucose and lipid profile disorders in rats

Nowadays the use of medicinal plants in the control and prevention of diseases such as diabetes are of utmost. Ziziphus vulgaris L. is one of the anti diabetic fruit. The aim of this study was to investigate the prevention effect of jujube fruit powder on factors such as glucose، low density lipoprotein، high density lipoprotein، cholesterol and triglyceride in diabetic rat. In this experimental study 30 male Wistar rats were designated into 3 groups as: control non diabetic، control diabetic and group treated with jujube fruit powder in 1mg/kgbw body weight for 2 weeks. The rats were diabetic by i. p. injection of streptozotocin (60 mg/kg). Animal were treated for another three week. In the end، blood sampling was done again and biochemistry factors were measured. Data analysis was done by statistical tests as: Kruskal-wallis، Friedman، Wilcoxon singed ranks and RM ANOVA. The result showed that treating with powder of jujube had no preventing effect on blood glucose increase. But treatment in animals before diabetes inducing resulted in blood glucose decreasing (P<0. 05). This treatment prevented cholesterol، LDL and triglyceride increase. It resulted in lipid decrease after inducing diabetes as well (P<0. 05). The amount of HDL was also decreased which was due to reduction in total lipid in serum. The results of this study showed that powdered jujube is useful in preventing and treatment of diabetes.