Vitamin D, the healthy and inflamed Immune System in Multiple Sclerosis

Multiple sclerosis (MS) is a complex disease in the central nervous system (CNS) and the most common inflammatory and degenerative disease in young adults. Most studies have shown that, vitamin D may interfere with the pathophysiology of MS within the CNS. CYP27B1 gene encodes the enzyme that catalyses the formation of the biological active metabolite 1,25(OH)2D form the abundant metabolite 25(OH)D. CYP27B1 is expressed on a variety of cells including neurons, glial cells and invaded lymphocytes. In this study we reviewed some different and new articles about the role of Vitamin D in MS. Then we selected the specific and the most recent data in this field. Among the multiple recently discovered actions of vitamin D, an immunomodulatory role has been documented in experimental autoimmune and in humans system like the central nervous system, pancreas. Furthermore, some clinical findings already strongly suggest that vitamin D status influences the relapse rate in MS and cancer. Our results suggest that beside the role of vitamin D in the relapse rate and radiological lesions in Iranian patients with MS In fact, many genetic and environmental risk factors like vitamin D appear to interact and contribute to MS, especially in young woman. As well as, they can serve as biomarkers to evaluate disease progression and therapeutic efforts.