Immunomodulating Effect of Cyclophosphamide on the Mice Infected with Candida albicans
Message:
Abstract:
Background and Objectives
Cyclophosphamide is an alkylating agent that stops the replication of DNA، which is used to treat various types of cancer and some autoimmune disorders. This study was aimed at then evaluating the immunomodulating effect of cyclophosphamide (Cy) on the immune system of vaccinated and non-vaccinated mice.
Materials and Methods
The study was performed on three groups of mice consisting of vaccinated، non-vaccinated and control groups. Vaccination was carried out by three separated courses of C. albicans injection intraperitoneally. Then، the vaccinated group received Cy on day zero and were challenged with lethal doses of C. albicans on days zero، one، 3، 6 and 12 post-Cy injection. Non-vaccinated group received Cy on day zero and similar to vaccinated ones were challenged with lethal doses of the organism. The control groups received just Cy on day zero and were sacrificed on days post-Cy injection. Then، the hemogram and the spleen and the renal tissues were studied microscopically and macroscopically.
Results
In the vaccinated group، an increase in survival time، the number of polymorphonuclear and the significant hyperplasia in the white pulp on days 6 and 12 post-Cy injection were noticed. In non-vaccinated ones، these factors had significant decrease on days 1 and 3.
Conclusion
It is concluded that the hyperplasia in the white pulp of spleen and an increasing in peripheral polymorphonuclear due to the selective effects of Cy could effectively protect the animal against C. albicans infection.
Language:
Persian
Published:
Journal of Advanced Biomedical Sciences, Volume:3 Issue: 4, 2014
Pages:
291 to 299
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