Effect of Estradiol valerate on pancreatic beta cells resistance in diabetic female rats by streptozotocin
Author(s):
Abstract:
Background
Diabetes mellitus (DM) is the most common metabolic disorder، with defective insulin secretion or insulin receptor function، or both. We examined the protective effect of estradiol against the destruction of pancreatic β-cells by streptozotocin (STZ). Material And Methods
This empirical research involved 56 adult female rats (180-200 g) randomized to: group 1، food and water; group 2، olive oil injection; group 3، STZ-induced DM; group 4، castrated rats; group 5، gonadectomy + STZ; group 6، gonadal hormone + STZ; group 7، gonadal hormone + STZ + gonadal hormone. Estradiol valerate was injected intramuscularly (5 mg/kg in group 6، 4 weeks before DM induction، and 5 mg/kg in group 7، 4 weeks before and 2 weeks after DM). Diabetes was induced by 60 mg/kg، intraperitoneal STZ (STZ; 20130 Sigma-Aldrich) in citrate buffer. Data were analyzed using SPSS 16 software. Results
In groups 6 and 7 (estradiol) blood glucose was higher than in groups 3and 5 and in group 7 was significantly higher (P ≤ 0. 05). Groups 6 and 7 also had higher serum insulin concentrations (P ≤ 0. 05) and absolute numbers of islet cells (P≤ 0. 05) compared to groups 3 and 5. Conclusion
Estradiol exerted a protective effect against early STZ-induced apoptotic damage to pancreatic β-cells.Keywords:
Language:
Persian
Published:
Iranian South Medical Journal, Volume:17 Issue: 2, 2014
Pages:
107 to 119
magiran.com/p1267081
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!