Control drug release delivery of new sulfametazine drug-conjugated poly p-styrene sulphonate system

Controlled drug release is one method for Stabilization of the drug concentration and its gradually releasing during the period of cure to make the most desire cure effect with decreasing the drug dose consumption. The application of polymers has been extended in this filed. This study includes the synthesis of p-styrene sulphonyl sulfametazine as monomer from p-styrene sulfonyl chlorid، and then the monomer is polymerized with AIBN (Azobis isobutyro nitrile) by free-radical polymerization mechanism، at the temperature 80 °C. The prepared products were characterized by 1H NMR and IR spectra. Then، the drug release ability of the polymer was test in buffer solution with PH = 1. 4 at the temperature of 37°C. The results from the UV absorption of polymer established that، the polymer is able to release drug.