Effects of Hydroethanolic Extract of Elaeagnus angustifolia on Pentylenetetrazole Induced Seizure in Male Mice
Author(s):
Abstract:
Background And Objectives
Epilepsy is a major cause of morbidity in patients. Elaeagnus angustifolia has antioxidant and anti-inflammatory activity. The effects of this traditional herbal medicine on Pentylenetetrazole (PTZ) -induced seizure have not been studied yet. The present study evaluated the effects of E. angustifolia on PTZ-induced seizure in male mice. Materials And Methods
30 male mice (30±5 g) were randomly divided into 5 groups including: control, normal saline, phenobarbital and E. angustifolia’s extract group at doses 200 and 400 mg/Kg. The groups were intraperitoneally administered 3 mg/kg phenobarbital, 200 and 400 mg/kg E. angustifolia’s extract for 2 hours before PTZ injection and 1 ml/kg normal saline for one week (n=6 per group). Seizure induced by administration of PTZ (1%) solution via tail vein of mice. All data were expressed as mean±SEM. One way ANOVA used for statistical evaluation. Statistical significance was accepted at P<0.05. Results
The administration of Elaeagnus angustifolia’s extract at doses 200 and 400 mg/kg was significantly increased Seizure threshold in PTZ-induced mice compared with control group (P <0.001). Conclusion
The hydroethanolic extract of Elaeagnus angustifolia has anticonvulsant effects, possibly through an interaction with inhibitory and excitatory system, antioxidant mechanisms, and ion chennel inhibition.Keywords:
Language:
Persian
Published:
Medical Journal of Tabriz University of Medical Science, Volume:36 Issue: 1, 2014
Page:
74
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