A macro-and microscopic local effect of silver nanoparticles on skin wound healing and some biochemical parameters of blood in mice

Presently, silver and its compounds are being used as an appropriate solution to treat burns, open and chronic wound infections. This study is, therefore aimed to evaluate the effects of silver nanoparticles on wound healing and some biochemical parameters of blood and kidney tissues in mice (Mus musculus). In this experimental study, 50 female BALB/c mice of (weighting 24.2±3.0 g) about 4 weeks were randomly divided into two groups: Ag-NPs and control. After making a wound in all groups, a volume of 50 microliters from the nanosilver solution (10ppm) was applied to the wound bed in the Ag-NPs group while in the control group no nanosilver solution was used but the wound area was washed by distilled water every day. Samplings were performed on days 2, 7, 14 and 21 of the experiment and the wound's surface area measured on succeeding days. The results of the present study show that the percentage of the wound healed in the treated group was significantly greater than in the control group so that the time required to heal in the former was 14 ± 0.82 days and in the latter 20.75 ± 1.03 (P<0.05). There were significant changes in potassium and blood urea nitrogen (BUN) among all groups studies (P<0.05). This study suggests that recovery with a 10 ppm solution of silver nanoparticles, while accelerates the process of wound healing, will notoriously influence on some biochemical parameters of blood. So, although solution of silver nanoparticles is beneficial for healing, it should be cautious in consuming it.