The Effect of Clorpyrifos Pesticide on Tissue Changes of Kidney in Female Mature Rats

Toxicity due to pesticide is the most wide spreading kind of toxicity which may have seen accidentally in persons who utilize these combinations for different purposes. The aim of this research is the investigation of the effect of clorpyrifos pesticide tissue changes of kidney in female mature rats. At this research 40 mature female rats from Wistar race were selected with 200±15 g and 2.5 months age and divided into 4 of 10 groups. Control group didnt receive any drug. Experimental 1, 2 and 3 groups received doses of 1, 2 and 4 mg/kg of clorpyrifos interpritoneally. After 14 days, rats were analyzed and kidney tissues extracted and were inserted at %10 formalin solutions. Then histological studies were performed and measurable factors are including diameter of cortical and medulla parts, glomerulus, Bowman's capsule, proximal and distal, Henle and collecting tubules. The results of this research show that the diameter of cortical part has significantly decreased in experimental 1 and 2 groups in comparison with control group. Collecting tubule diameter also at experimental 1, 2 and 3 groups has significantly increased (P<0.05). The clorpyrifos with effecting on cortical parts of kidney and collecting tubules resulted in kidney disorder that probably this effect is mediated by the oxygen active kinds mechanism.