The correlation of factor VIII and von Willebrand levels with clinical symptoms in obligate carriers of hemophilia A in Isfahan

Bleeding tendency in obligate carriers of hemophilia A has been found since several years ago; some of haemophiliacs with factor levels of 40-60% also have abnormal bleeding. The present study is to measure factor VIII and von Willebrand levels and evaluate their correlation with clinical finding in obligate carriers. In this cross-sectional study conducted 49 obligate carriers of Haemophilia A. F.VIII, vWF: Ag, PT, and APTT levels were checked and their correlationship with the bleeding score was evaluated and analyzed. Fourty-Nine Obligate carriers included in the study. The mean of PT, PTT, F.VIII, vWF: Ag and bleeding score (BS) were 12.6 ± 1.3, 36.3 ± 4.2, 52.5 ± 22.6, 83.7 ± 35.2, and 1.5 ± 1.7, respectively. The present study showed only 4% (2) of the carriers having had bleeding score (BS) equal to 5 and higher. Only F.VIII / vWF: Ag positively correlated with BS significantly (p = 0.006). The present study showed that PT, PTT, and F.VIII levels and the bleeding score alone could not be helpful in screening obligate carriers. It seems that only determination of F.VIII/vWF: Ag ratio be helpful hn carrier states. But definitive diagnosis carrier states is by molecular genetic testing.