Research of Nanocurcumin Effect on Progression and Adhesion to Extracellular Matrix Rate in SW480 Cancer Cells

Back ground: Adhesion to extracellular matrix is a main necessity for invasion and malignancy in cancer cells. As a result، current treatment for patients with malignant tumors is inhibition of tumor cell movement and invasion. Among the herbal medicine، curcumin has long been considered by researchers. However، the lack of solubility of this compound in aqueous environments، has reduced its bioavailability. numerous carriers were suggested so far، however، any perfect formulation has not yet been found. In this study we used this medication mounted on a new and native carrier of nano particle to investigate its effects on the adhesion to the extracellular matrix and progression ability of SW480 cells. In present study، in order to produce nanocurcumin، net curcumin and native nanoparticle of O-400 generation were used for the production of nanocurcumin، for getting cellular viability and IC50 rate، was used MTT assay and for evaluating cellular adhesion measure was used adhesion assay. The results showed that nanocurcumin exerted an inhibitory effect with the little dosages (0-15 µM) on the cellular viability and adhesion rate of SW480 cells and the IC50 concentration was obtained in the range of about 15. 86، 11. 57 and 7. 64 µM at 24، 48 and 72 h post-treatment of nanocurcumin. As a result، the nanocurcumin combinational medicine that has been approved in previous studies and showed high efficacy to inhibit the growth of cancerous tumors، can be known as an acceptable treatment option and we can hope its cancer preventive agent in future.