Inducing Effect of Aloe Vera Gel Extract on Epithelial Growth Factor Receptor Gene Expression in Cutaneous Wounds of Male Mice Balb/c

Present study was done to assess the effects of Av gel on some molecular aspects in wound healing process of mouse damaged skin. 36 Male mice balb/c were used. Animals were divided into 3 groups; negative control (without wound), sham-operated (wound treated with physiological serum) and experimental (wound treated with Av gel extract). In each group, two equal full-thickness wounds were made on the mice back sides. Experimental group received daily a dose of Av gel extract on the top of wound sites (without bandage) for a period of 16 days. On 8th and 16th post wounding day, for the purpose of EGF receptor gene expression evaluation and lipid peroxidation (LPO), skin and blood serum sampling were done respectively and data were analyzed by Repeated measures ANOVA at significant level p<0.05 Av gel extract treatments increased EGF receptor gene expression in the wound area. Wound healing percentage was also increased in experimental groups compared to sham group. It was also found that the amount of LPO end-product in blood sera was reduced to Av treated mice in the end of test. Av gel extract can induce EGF receptor gene expression in mice damaged skin, and play a pivotal role in wound healing process.