Premature rupture of membranes and maternal blood lead levels in early pregnancy

Introduction and Premature rupture of membranes (PROM) is one of the leading causes of preterm delivery and Potential adverse in prenatal. Given the importance of certain factors and lack of it's predisposing to this complication, this study aimed to investigate the relationship between PROM and the mother's blood lead level in first half of pregnancy. This longitudinal study has done on 110 pregnant women at 14-20 weeks gestational age at clinics in teaching hospitals affiliated to Tehran University in the years 1389-1390.Obtainig blood samples to measure lead in enrollment and demographic and pregnancy questionnaire was completed. Data were analyzed by SPSS16 software and Corelation Spearman, χ2, Man-Whitney U, Linear regression tests and P<0.05 was taken as the significant level. The averagematernal age 26/7 ± 4/3 years, the average maternal blood lead level of 4/7 ± 4/9 μg/dl and premature rupture of membranes 6/8% was reported. According to chi-square test results between blood lead and PROM, there was no significant relationship (P =0/8). In this study, results showed there was no significant relationship between blood lead levels and premature rupture of membranes.