Association of -420 C/G Polymorphism in the Promoter of Resistin Gene and Susceptibility to Obesity

Obese people are at risk of a number of diseases which can lead to further morbidity and mortality. The resistin hormone is secreted from the adipose tissue and the elevated levels of this hormone have been linked to obesity and insulin resistance. Thus, the resistin gene represents a potential candidate for the etiology of insulin resistance and obesity. In this study, we analyzed the possible association of -420 C/G resistin gene polymorphisms with overweight and obesity risk in Iranian population. This case-control study was done on 289 subjects divided into control (BMI<25) and obese (BMI≥25) groups based on the body mass index. Resistin -420 C/G gene polymorphism was analyzed using the PCR-RFLP method. The GG genotype frequency was 15% and 85% in control and obese groups, respectively. There was a significant association between GG genotype and susceptibility to obesity after adjusting for sex and age (OR: 3.9, 95%CI: 1.7-8.7, P: 0.001). In conclusion, Resistin -420 C/G gene polymorphism was associated to susceptibility to obesity.