Effect of vitamin D supplementation on symptoms and C - reactive protein among patients with migraine

Migraine is the most common form of headache around the world including Iran. In recent years, particular notice has been made to the relationship between vitamin D and migraine. Therefore, the purpose of the current study is to investigate the relationship between serum vitamin D levels and CRP and migraine symptoms in patients. This study was carried out as a randomized, double-blind clinical trial. Patients were randomly assigned for either intervention or control groups. Patients consumed a vitamin D supplement or placebo (50000 IU/ week) during 10 weeks. Before and after the intervention, serum levels of vitamin D and CRP were measured and migraine symptoms were assessed. To assess the effect of vitamin D supplements on migraine symptoms including severity, duration, frequency of headache attacks and headache diary result (HDR), multivariate and uni-variate analysis of covarients were used as statistical methods of analysis. Significant differences were observed in mean headache frequency and diary result (HDR) between the two groups (P=0.06 and P=0.04). However, the difference in mean migraine frequencies between the groups displayed a significance threshold (P=0.06). The relationship between migraine headaches and C - reactive protein (CRP) was not determined. the outcome of this study suggests that vitamin D supplements are effective in reducing migraine symptoms including frequency of headache attacks and headache diary result in patients.