Effect of Aloe Vera Hydroalcoholic Extract on Blood Glucose, Serum Insulin and the Key Enzymes in Metabolic Pathways of Glycolysis and Gluconeogenesis in Hepatocytes of Type 1 Diabetic Rats
Message:
Abstract:
Background And Objective
Recently, it is considered the role of hypoglycemic agents specially medicinal plants derivatives in treatment of diabetes mellitus. Aloe Vera contains phenolic compounds and flavonoids with antioxidant properties that reduces the complications of the disease.The aim of study was to investigate the effects of hydroalcoholic extract of Aloe Vera in serum levels of glucose and insulin and key enzymes in metabolic pathways of glycolysis and gluconeogenesis in streptozotocin-induced diabetic Wistar rats.
Materials And Methods
A total of 50 rats (initial weight of 220 ±10 g) were divided into five groups. Two months after treatment with Aloe Vera extract, the rats were sacrificed and blood glucose and serum insulin levels were measured. It was also isolated the liver then, extracted mRNA from it, expression levels of Glucokinase and Phosphoenol pyruvate carboxy kinase enzymes were measured by Real Time PCR.
Results
The results showed that the extract of Aloe Vera at doses of 100, 200 and 400 mg/kg increase insulin secretion (p<0.05), hypoglycemia (p<0.001), increasing expression of Glucokinase enzyme (p<0.05) and reducing expression of the Phosphoenol pyruvate carboxy kinase enzyme (p<0.05) in diabetic rats.
Conclusion
Not only dose Aloe Vera hydroalcoholic extract influence on insulin secretion, it also affects on key enzymes gene expression of Glycolysis and Gluconeogenesis pathways. Hence, this extract can be effective for improvement of diabetic complications.
Language:
Persian
Published:
Journal of Rafsanjan University Of Medical Sciences, Volume:13 Issue: 8, 2014
Pages:
668 to 682
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