Early Or Late Renal Replacement Therapy In AKI Patients; The Most Challenging Decision

It was designed as a pilot study in an academic medical center in Iran. The study started with 30 AKI patients at medical ward who were divided in to two groups through 1:1 randomization and received RRT (IHD) as “early group” or “late group”.

The SPSS statistical software was used for analysis. At the start of the RRT, eGFR was 10.62 ± 7.25 (ml/min/1.73 m2) in ED group versus 11.54 ± 6.52 in LD group. After 28 days follow-up, changing in eGFR was + 48.68± 39.43 in ED and +31.27 ± 23.28 in LD group, the difference was not significant in two groups (P= 0.15). Difference in duration of regaining renal function (duration that urine output recovered to 60 ml/h or eGFR rose 30% or more) in two groups was not significant (P=0.059; 8.7 in ED and 6.8 days in LD group).The mortality rate was the same in two groups.

The earlier initiation of RRT versus late RRT didn’t have any significant impact on kidney or patient survival.