The effect of Epigallocatechin-3-Gallate on Spatial Memory after Demyelination Induced by Lysolecithin in Rat Hippocampus Formation
Message:
Abstract:
Background And Objectives
Multiple Sclerosis (MS) is an autoimmune disorder in central nervous system characterized by neuroinflammation. In this study, the effect of Epigallocatechin-3-Gallate (EGCG) on learning and spatial memory was investigated following a demyelination induction using lysolecithin injection into the rat hippocampus.
Materials And Methods
In this experimental study, for the demyelination induction, 2µl lysolecithin (LPC) was injected streotaxically into the dentate gyros. Then, animals received 30mg/kg catechin for 7, 14, and 28 days after demyelination induced by lysolecithin. Subsequently, the spatial memory was investigated by a radial maze. Repeated measurement used for statistical evaluation.
Results
The impairment of the spatial memory was more significant 7 and 14 days after the LPC injection. Hence, food finding time has increased significantly compared to the control group (P<0/001). Moreover, the administration of EGCG has improved the spatial memory so that receiving EGCG for a longer time e.g. 28 days after demyelination induction can significantly recover the learning and spatial memory compared to the LPC-receiving group (P<.001).
Conclusion
The long-term administration of EGCG can improve the spatial memory and learning of rats. Hence, it can be suggested as a treatment for demyelinated disease such as MS.
Language:
Persian
Published:
Medical Journal of Tabriz University of Medical Science, Volume:36 Issue: 5, 2015
Page:
88
magiran.com/p1377863  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!