Investigation of E-cadherin expression in Peripheral Blood of patients with breast cancer in a population from southern Iran

Breast cancer is the most common malignancy in women, and is considered as the second causative factor in cancer mortality. E – Cadherin is a transmember glycoprotein and play a essential role in cell-cell adhesion. It seems that E-cadherin Gene expression can plays a role in suppressor of invasion and metastasistumor. The aim of this study was to evaluate the correlation of E-cadherin Gene expression with breast cancer in the women population of southern Iran. 30 patients and 30 healthy individuals as control participated in this case-control study. mRNA extracted from peripheral blood. Real Time PCR technique was used to determine the Gene expression. The statistical analysis was performed by the software SPSS and Mannwithny test. The results indicated that there is no significant difference in level of E- cadherin Gene expression in patients with breast cancer and the control group (Pv>0.05). Furthermore, we found no significant correlation between the E- cadherin Gene expression with the clinicopathological factors in the patients. it seems that E- cadherin Gene expression, plays no important role in increasing the susceptibility of women to breast cancer in the population of southern Iran.