Association of Mdr1 Gene C1236t Polymorphism with Idiopathic Male's Infertility in Guilan Population
Infertility is defined as the inability of the couples to achieve pregnancy after 12 months of unprotected intercourse. P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells and has a protective role in sensitive tissues such as testis. MDR1 gene is located on q21.1 of chromosome 7. Hence, this study aimed to assess the association of MDR1 polymorphism and idiopathic male infertility.
In this study (case- control), DNA was extracted from blood leukocytes of 136 male patients with idiopathic infertility as well as 130 healthy men. Genotypes were determined by using PCR-RFLP technique and EcoO109I enzyme.
The genotypes frequencies of CC, CT and TT in patient group were 19.12%, 39.70% and 41.18%, respectively, and the genotype frequencies of CC, CT and TT in control group were 12.30%, 61.54% and 26.16%, respectively.
The study findings revealed that a significant association was found between MDR1 polymorphism and idiopathic infertility (P= 0.001). Therefore, the results suggest that CT heterozygous genotype has a protective effect on male fertility (P= 0.01, OR= 0.41; 95%CI: 0.23- 0.84). However, to achieve more accurate results, it is necessary to examine a larger target population.
Journal of Shaeed Sdoughi University of Medical Sciences Yazd, Volume:23 Issue: 1, 2015
1796 to 1804  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
In order to view content subscription is required

Personal subscription
Subscribe for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!