The Effect of Vitamin D and Calcium Plus Vitamin D on Sleep Quality in Pregnant Women with Leg Cramps: A Controlled Randomized Clinical Trial

Evidence indicates that sleep may be affected by using vitamins and minerals or lack of them. This study aimed to determine the effects of vitamin D and calcium-vitamin D in the treatment of sleep disorders in pregnant women with leg cramps. This triple-blind randomized controlled clinical trial took place on 126 pregnant women referred to Tabriz health centers، Tabriz، Iran، in 2013-2014. Subjects were allocated in to three groups، using block randomization. The groups received vitamin D، calcium-vitamin D and placebo pills daily for 60 days. Sleep score was measured before and after the intervention، using the Pittsburgh Sleep Quality Index. ANCOVA test was used for data analysis. Controlling baseline score before the intervention، there was no significant differences in the sleep quality score after intervention between the group receiving calcium-vitamin D and the control group (adjusted difference: -0. 3، 95% confidence interval: -1. 4 to 2. 1)، the group receiving vitamin D and controls (adjusted difference: -0. 007، 95% confidence interval: -1. 7 to 1. 7) and between the two groups receiving calcium-vitamin D and vitamin D (adjusted difference: -0. 3، 95% confidence interval: -1. 4 to 2. 1). Also، there was no significant difference between the groups in sleep quality subscales (P > 0. 05). The results show that calcium-vitamin D and vitamin D does not effect on improving the sleep quality in pregnant women with leg cramps.