Preparation of Nanocomposite Fibrous Scaffolds of Poly-3-hydroxybutyrate/Bioactive Glass by Electrospinning Method for Bone Tissue Engineering

Recently، composite scaffolds prepared by electrospinning have shown desirable properties for tissue engineering applications. In this study، first the nBGs were prepared via the sol-gel technique، then، the electrospun PHB/nBG nanocomposite scaffolds (with 7. 5، 10 and 15 wt% of nBGs) were fabricated. The nanoparticles and scaffolds were characterized by Scanning Electron Microscopy (SEM)، X-ray diffraction spectrometer (XRD)، X-rayfluorescence spectroscopy (XRF)، Fourier transform infrared spectroscopy (FTIR). Results showed that nanoparticles with an amorphous structure mainly had a particle size of less than 70 nm. All the nano-fibrous scaffolds had a uniform distribution of interconnected porosities with fiber diameters ranging from 326. 1 nm to 1. 276 micrometer. Composite scaffolds having nanoparticle concentrations higher than 7. 5 wt%، tend to agglomerate. In addition، the FTIR results showed a favorable interaction between the polymer and nBGs. Therefore، the proposed PHB/nBG scaffolds prepared in this study can be considered as good candidates for bone tissue engineering applications.