The Effect of Vitamin D Supplementation on Markers of Lipid Levels in Patients with Nonalcoholic Fatty Liver

Nonalcoholic fatty liver is a very common chronic liver disease. Disease, gradually causes liver cirrhosis and eventually liver transplantation. In patients with fatty liver, disorders in lipid parameters exist. Purpose of this study was to investigate the effect of vitamin D supplementation on lipid parameters in patients with nonalcoholic fatty liver. In thisrandomized parallel clinical trial study, 60 patients with non-alcoholic fatty liver disease participated in the intervention and placebo groups. For 10 weeks, the intervention and placebo groups received capsules of 50,000 IU vitamin D or placebo, respectively. Lipid parameters were measured at the beginning and end of the study. Nonalcoholic fatty liver was diagnosed by ultrasound. Data were analyzed using analysis of covariance (ANCOVA) and ordinal regression tests. In intervention group, the serum vitamin D levels were significantly increased compared to the placebo group. Total cholesterol as well as low-density lipoprotein (LDL) significantly decreased in intervention group, too. The effect of vitamin D supplementation was not significant on other variables. Vitamin D supplementation can reduce total cholesterol and LDL in patients with nonalcoholic fatty liver. But more researches must be conducted with large sample sizes and strong designs to confirm these findings.