The Frequency of CA15-3, CA125, CA19-9 in Patients With Hepatitis B and C

Hepatitis B is considered as a cause for serum hepatitis which may lead to liver cells cancer. Hepatitis C is major cause of chronic hepatitis in developed countries. Information about tumor markers in patients with HBV and HCV in Iran population is limited. Therefore, this study aimed to determine the role of tumor markers CA15-3, CA125, CA19-9 in patients with hepatitis B and C who refer to Guilan Liver and Digestive Disease Research Center. Patients and In this descriptive cross sectional study on serum samples from 80 patients with hepatitis B and C at Guilan Liver and Digestive Disease Research Center has been conducted from October 2012 to October 2013 in terms of listed tumor markers via ELISA method. The findings showed that no increases in serum levels of tumor marker CA19-9 has been seen in patients with hepatitis. In patients with hepatitis B, there was an increasing at levels of tumor marker CA15-3 (P = 0.04). Also in patients with hepatitis C, increasing in the tumor marker CA125 were observed (P = 0.02). The study showed that the tumor marker CA 15 - 3 and tumor marker CA125 was high respectively in hepatitis B and hepatitis C, but this increasing is not for malignancy, but further studying seemed to be necessary because of low size of samples to find the reasons of the increasing.