Comparison of the Effectiveness of Mellisan Gel and Acyclovir 5% Cream in the Improvement of Recurrent Herpes Labialis
Message:
Abstract:
Background And Objective
Recurrent herpes labialis is a common infection of the mouth area, caused by herpes simplex virus. This infection appears in the mucus or lip skin and is commonly known as oral herpes. The purpose of this study was to compare the effectiveness of Mellisan gel and acyclovir 5% cream in the improvement of recurrent herpes labialis.
Methods
This double-blind clinical trial was conducted on 60 patients (14 men and 46 women), with the average age of 23.8 years (minimum of 20 and maximum of 32 years) and a prior history of recurrent herpes labialis three times a year. The previously-coded medicines were randomly distributed among patients. The subjects were asked to apply the cream or gel locally on the infected region three times a day, according to the manufacturer's instructions. All patients were examined within one, two, four and seven days after using the cream or gel to determine the changes in pain intensity, size of the ulcer, inflammation and recovery time. IRCT: 13870819144281.
Findings
Mellisan gel and acyclovir cream were not significantly different in reducing the size of the ulcer, inflammation or the associated side-effects. Mellisan gel was accompanied by a significant reduction in pain intensity in patients on the second and fourth days of the examination (p=0.0001 and p=0.02, respectively). Moreover, on the second day, there was a significant difference in recovery (p=0.001).
Conclusion
The results of this study suggested that Mellisan gel is more effective than acyclovir cream in terms of pain reduction and recovery, whereas no significant difference was observed regarding the size of the ulcer or inflammation. Also, the administration of Mellisan gel and acyclovir cream was associated with no side-effects.
Language:
Persian
Published:
Journal of Babol University of Medical Sciences, Volume:17 Issue: 7, 2015
Pages:
15 to 21
magiran.com/p1410984  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!